According to state police, two-year-old Alexis Weber was abducted around 7:00 p.m. on Sunday from 2200 West Front Street in Berwick.
Alexis is described as approximately three feet tall, 30 lbs., with blond hair and blue eyes.
She was last seen wearing a white coat, a blue polka dot shirt, and black pants, police say.
Alexis was inside a 2005 yellow Ford Mustang convertible with Pennsylvania registration HWN-1367, according to police.
State troopers say the car was stolen, heading towards Laporte, in Sullivan County, Pa.
Anyone with information concerning this incident is asked to call 911.