The fire broke out around 9:30 a.m. at a bi-level home located at 168 Evans Street in Brookville Borough.
It is believed that the home is a complete loss.
Officials say the cause of the fire remains under investigation.
No injuries were reported.
Brookville Volunteer Fire Company, Corsica Fire Company, Pine Creek Township Fire Company, DuBois Fire Department responded, and Jefferson County EMS responded to the scene.