Police say 26-year-old Emily S. Hale, of Reynoldsville, and 36-year-old Charles S. Brown, of Punxsutawney, were involved in the collision.
Hale was traveling southbound on SR 119 in a 2011 Chevrolet Cruze. Brown was also southbound on SR 119 in a 2007 Jeep Wrangler and was stopped due to a vehicle turning left into a driveway in front of him, according to police.
Hale failed to stop her Chevrolet within a safe distance and impacted the rear of the Jeep.
The Chevrolet came to a final rest on the southbound shoulder, and the Jeep came to a final rest in a yard on Sykes Street Extension.
Both units were facing a southerly direction.
Hale and two female passengers, ages 4 and 1, were injured in the collision.
Sykesville Ambulance transported them to Penn Highlands DuBois.
The severity of the injuries is unknown.
Hale was using a seat belt, and the children were using child safety seats.
Brown was not injured; he was using a seat belt.
Hale was issued a traffic violation.
State police were assisted at the scene by Sykesville Ambulance, DuSan Ambulance, and Sandy Township Fire Department.